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Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors.
The organizer is one of the earliest structures to be established during vertebrate development and is crucial to subsequent patterning of the embryo.We have previously shown that the SoxB1 transcription factor, Sox3, plays a central role as a transcriptional repressor of zebrafish organizer gene expression.Recent data suggest that Fgf signaling ha
A new FACS approach isolates hESC derived endoderm using transcription factors.
We show that high quality microarray gene expression profiles can be obtained following FACS sorting of cells using combinations of transcription factors.We use this transcription factor FACS (tfFACS) methodology to perform old taylor whiskey 1933 price a genomic analysis of hESC-derived endodermal lineages marked by combinations of SOX17, GATA4, a
Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system
old taylor whiskey 1933 price Background: Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids on stimulation, such as pH, temperature and ionic change.Aim: To develop hydrogels that are sensitive to stimuli, i.e.pH, in the cul-de-sac of the eye for provid